Always best to use a GPO to make those changes on your clients: http://technet.microsoft.com/en-us/library/dd939933%28v=ws.10%29.aspx
Via Landesk, I recommend creating a Provisioning Template to carry out this registry change. For the new template you can leave "Boot Environment" to not applicable but set Target OS to Windows. Open the new template and create your list of tasks under System Configuration. There's actually an action type called "Update Registry" so you're lucky.
One way to do this and have it mimic a GPO is use a custom vulnerability. That way if any of the reg items were changed, and the custom vulnerability was set to autofix it would change it back to the prescribed settings. It is not that difficult and can be automagic.
create a .reg file with notepad containing your values, and create a batch file with the following command line :
Regedit.exe /S [name].reg
That's all folks ;-)
Choose your distribution time carefully, and perhaps reboot your computers after with the following command line
shutdown -r -f -m \\127.0.01 -t 0
One thing is that I agreed ChrisA and Zman. The better way is GPO distribution.