You can do a scan with an output file (ldiscn32 with /o as the option, like /o=C:\MyScan.scn) and then manually copy and paste that output scan to the core server under \\Server\ldmain\ldscan. At that point it should be processed.
Reading this over again I would guess you want to do a vulnerability scan, not an inventory scan. My bad!
The answer is actually, no. You need a connection.